Chris Chipot
Centre National de la Recherche Scientifique Research Director
Adjunct professor of physics, University of Illinois at Urbana-Champaign

Phone : +33-(0)3-72-74-50-75
E-mail : and

Biographical sketch
Chris Chipot received his PhD in Theoretical Chemistry in 1994 from the Henri Poincaré University, in France, conducting research on intermolecular potentials with a fellowship from the Roussel Uclaf Institute. Following a post-doctorate in the Department of Pharmaceutical Chemistry of the University of California in San Francisco, he became a National Research Council post-doctoral fellow at the NASA Ames Research Center. He joined the CNRS in 1996 at the University of Lorraine, where he worked on the modeling of the biological membranes by means of computer simulations, while developing original approaches for free-energy calculations and the exploration of rare events. His developments also extend to the accurate description of intermolecular interactions, including induction phenomena. He received his habilitation in 2000 and was promoted research director in 2006. Since 2012, he has been directing an Associate International Laboratory established between the CNRS and the University of Illinois at Urbana-Champaign. He has a joint appointment with the Department of Physics at the University of Illinois at Urbana-Champaign.

Research areas
Modeling of protein-membrane interaction, free-energy calculations in biological systems, and development of intermolecular interaction potentials.

Scientific production
221 articles, published or in press, and 3 under review. >30,700 citations, h-index 58, i10-index 189 (publications cited at least ten times). 14 book chapters. 1 science book. Source Google Scholar. Top 0.6% in the Stanford world ranking of scientists. 82 invited conferences at international scientic events. 40 communications at national and internationalmeetings. 66 seminars. 6 public presentations.

Selected publications
  1. Gumbart, J. C.; Roux, B.; Chipot, C. Efficient determination of protein-protein standard binding free energies from first principles. J. Chem. Theor. Comput. 2013, 9, 3789-3798.
  2. Comer, J.; Gumbart, J. C.; Hénin, J.; Lelièvre, T.; Pohorille, A.; Chipot, C. The adaptive biasing force method: Everything you always wanted to know, but were afraid to ask. J. Phys. Chem. B 2015, 119, 1129-1151.
  3. Chipot, C.; Dehez, F.; Schnell, J. R.; Zitzmann, N.; Pebay-Peyroula, E.; Catoire, L. J.; Miroux, B.; Kunji, E. R. S.; Veglia, G.; Cross, T. A.; Schanda, P., Perturbations of native membrane protein structure in alkyl phosphocholine detergents: A critical assessment of NMR and biophysical studies, Chem. Rev. 2018, 118, 3559–3607.
  4. Pohorille, A.; Jarzynski, C.; Chipot, C. Good practices in free-energy calculations. J. Phys. Chem. B, 2010, 114, 10235-10253 .
  5. Phillips, J. C.; Hardy, D. J.; Maia, J. D. C.; Stone, J. E.; Ribeiro, J. V.; Bernardi, R. C.; Buch, R.; Fiorin, G.; Hénin, J.; Jiang, W.; McGreevy, R.; Melo, M. C. R.; Radak, B. K.; Skeel, R. D.; Singharoy, A.; Wang, Y.; Roux, B.; Aksimentiev, A.; Luthey-Schulten, Z.; Kalé, L. V.; Schulten, K.; Chipot, C.; Tajkhorshid, E. Scalable molecular dynamics on CPU and GPU architectures with NAMD. J. Chem. Phys. 2020, 153, 044130.

Recent publications

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction
Anne-Sophie Banneville; Claire Bouthier de la Tour; Salvatore De Bonis; Cecilia Hognon; Jacques-Philippe Colletier; Jean-Marie Teulon; Aline Le Roy; Jean-Luc Pellequer; Antonio Monari; Francois Dehez; Fabrice Confalonieri; Pascale Servant; Joanna Timmins;
Nucleic Acids Research (2022) 50 (13): 7680-7696
Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803
Eva Mocchetti; Laura Morette; Guillermo Mulliert; Sandrine Mathiot; Benoit Guillot; Francois Dehez; Franck Chauvat; Corinne Cassier-Chauvat; Celine Brochier-Armanet; Claude Didierjean; Arnaud Hecker;
Biomolecules (2022) 12 (10): 1466
Galvani Offset Potential and Constant-pH Simulations of Membrane Proteins
Olivier Bignucolo; Christophe Chipot; Stephan Kellenberger; Benoit Roux;
The Journal of Physical Chemistry B (2022) 23 (36): 6868-6877


- Renewal of the Laboratoire International Associé CNRS-University of Illinois at Urbana-Champaign on January 2021
- 新的分子动力学讲义 (Dissemination).
- Kudos to Margaret Blazhynska and Emma Goulard Coderc de Lacam on their DrEAM fellowship supporting their training in the Tajkhorshid and Gumbart research groups.


Laboratoire International Associé
Unité mixte de recherche n°7019
Université de Lorraine, B.P. 70239
54506 Vandoeuvre-lès-Nancy Cedex, France
Phone: +33(0)3 72 74 50 75
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