Jeff Comer 
Centre National de la Recherche Scientifique
E-mail :

Biographical sketch

Jeffrey Comer was born in the state of Ohio, USA, in 1983. He received his B.Sc., summa cum laude, in physics in 2005 from the University of Akron. He was then accepted into the graduate physics program at the University of Illinois at Urbana-Champaign, where he joined the group of Aleksei Aksimentiev and investigated systems at the interface of biology and nanotechnology through molecular dynamics, Brownian dynamics, and other computational methods. He received his Ph.D. in 2010, defending a dissertation entitled "Nanopore Technology for DNA Sequencing." After a short post-doctoral position with the Aksimentiev Group, in 2011 he became a post-doctoral researcher at Fraunhofer Chile Research in Santiago, Chile under the supervision of Fernando D. González-Nilo with support from the Universidad de Talca and Universidad Andres Bello. While in Chile, he performed computational studies of dendrimer–nucleic acid interaction. In 2013, he moved to Nancy, France and became a CNRS researcher in the group of Christophe Chipot. Jeff's research interests include improved dynamical models of nanoscale biological and technological systems and method development for accessing broad spatial and temporal scales.

Research areas
Statistical mechanics simulations, free-energy calculations systems, nanomolecular systems.

Selected publications
  1. Comer, J.; Chipot, C.; González-Nilo, F.D., Calculating Position-Dependent Diffusivity in Biased Molecular Dynamics Simulations, J. Chem. Theor. Comput. 2013,
  2. Comer, J.; Aksimentiev, A., Predicting the DNA Sequence Dependence of Nanopore Ion Current Using Atomic-Resolution Brownian Dynamics, J. Comput. Chem. C 2012, 116, 3376–3393.
  3. Carr, R.; Comer, J.; Ginsberg, M.; Hock, V.; Aksimentiev, A., Atoms-to-microns Model for Small Solute Transport through Sticky Nanochannels, Lab on a Chip 2011, 11, 3766–3773.
  4. Carr, R.; Comer, J.; Ginsberg, M.; Hock, V.; Aksimentiev, A., Microscopic Perspective on the Adsorption Isotherm of a Heterogeneous Surface, J. Phys. Chem. Lett. 2011, 2, 1804-1807.
  5. Comer, J.; Dimitrov, V.; Zhao, Q.; Timp, G.; Aksimentiev, A., Microscopic Mechanics of Hairpin DNA Translocation through Synthetic Nanopores, Biophys. J. 2009, 96, 593–608.

Recent publications

Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction
Anne-Sophie Banneville; Claire Bouthier de la Tour; Salvatore De Bonis; Cecilia Hognon; Jacques-Philippe Colletier; Jean-Marie Teulon; Aline Le Roy; Jean-Luc Pellequer; Antonio Monari; Francois Dehez; Fabrice Confalonieri; Pascale Servant; Joanna Timmins;
Nucleic Acids Research (2022) 50 (13): 7680-7696
Biochemical and Structural Characterization of Chi-Class Glutathione Transferases: A Snapshot on the Glutathione Transferase Encoded by sll0067 Gene in the Cyanobacterium Synechocystis sp. Strain PCC 6803
Eva Mocchetti; Laura Morette; Guillermo Mulliert; Sandrine Mathiot; Benoit Guillot; Francois Dehez; Franck Chauvat; Corinne Cassier-Chauvat; Celine Brochier-Armanet; Claude Didierjean; Arnaud Hecker;
Biomolecules (2022) 12 (10): 1466
Galvani Offset Potential and Constant-pH Simulations of Membrane Proteins
Olivier Bignucolo; Christophe Chipot; Stephan Kellenberger; Benoit Roux;
The Journal of Physical Chemistry B (2022) 23 (36): 6868-6877


- Renewal of the Laboratoire International Associé CNRS-University of Illinois at Urbana-Champaign on January 2021
- 新的分子动力学讲义 (Dissemination).
- Kudos to Margaret Blazhynska and Emma Goulard Coderc de Lacam on their DrEAM fellowship supporting their training in the Tajkhorshid and Gumbart research groups.


Laboratoire International Associé
Unité mixte de recherche n°7019
Université de Lorraine, B.P. 70239
54506 Vandoeuvre-lès-Nancy Cedex, France
Phone: +33(0)3 72 74 50 75
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