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Structural basis for broad HIV-1 neutralization by a novel MPER-specific human broadly neutralizing antibody. Potent and broadly neutralizing antibodies (bNAbs) are the hallmark of HIV-1 protection by vaccination. The membrane-proximal external region (MPER) of the HIV-1 gp41 fusion protein is targeted by the most broadly-reactive HIV-1 neutralizing antibodies. Here we report on a new anti-MPER bNAb, LN01, isolated from lymph-node derived germinal center B cells of an Elite Controller, which neutralizes 92% of a 118-strain virus panel. MPER and the transmembrane region (TM) form a continuous helix in complex with LN01, whereas the tilted TM orientation allows LN01 to interact simultaneously with the peptidic component of the epitope and with membrane via two specific lipid binding sites of the antibody paratope. Although LN01 carries a high load of somatic mutations, most of the key residues interacting with the MPER epitope and lipids are germline encoded, lending support for the LN01 epitope as a candidate for lineage-based vaccine development. Cell Host & Microbe, 2019.

Recent publications


Structural Basis for Broad HIV-1 Neutralization by a Novel MPER-Specific Human Broadly Neutralizing Antibody
Dora Pinto; Craig Fenwick; Christophe Caillat; Chiara Silacci; Serafima Guseva; Francois Dehez; Christophe Chipot; Sonia Barbieri; Andrea Minola; David Jarrossay; Georgia D. Tomaras; Xiaoying Shen; Agostino Riva; Maciej Tarkowski; Olivier Schwartz; Timothee Bruel; Jeremy Dufloo; Michael S. Seaman; David C. Montefiori; Antonio Lanzavecchia; Davide Corti; Giuseppe Pantaleo; Winfried Weissenhorn;
SSRN Electronic Journal (2019)
Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases
Zhiyou Zong; Qiyu Li; Zhangyong Hong; Haohao Fu; Wensheng Cai; Christophe Chipot; Huifeng Jiang; Dongyuan Zhang; Shulin Chen; Xueguang Shao;
Journal of the American Chemical Society (2019) 141 (36): 14451-14459
Triggering Tautomerization of Curcumin by Confinement into Liposomes
Maxime Girardon; Stephane Parant; Antonio Monari; Francois Dehez; Christophe Chipot; Ewa Rogalska; Nadia Canilho; Andreea Pasc;
ChemPhotoChem (2019) 31 (121-

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